10 research outputs found
A bright, high rotation-measure FRB that skewers the M33 halo
We report the detection of a bright fast radio burst, FRB\,191108, with
Apertif on the Westerbork Synthesis Radio Telescope (WSRT). The interferometer
allows us to localise the FRB to a narrow 5\arcsec\times7\arcmin ellipse by
employing both multibeam information within the Apertif phased-array feed (PAF)
beam pattern, and across different tied-array beams. The resulting sight line
passes close to Local Group galaxy M33, with an impact parameter of only
18\,kpc with respect to the core. It also traverses the much larger
circumgalactic medium of M31, the Andromeda Galaxy. We find that the shared
plasma of the Local Group galaxies could contribute 10\% of its
dispersion measure of 588\,pc\,cm. FRB\,191108 has a Faraday rotation
measure of +474\,\,rad\,m, which is too large to be explained by
either the Milky Way or the intergalactic medium. Based on the more moderate
RMs of other extragalactic sources that traverse the halo of M33, we conclude
that the dense magnetised plasma resides in the host galaxy. The FRB exhibits
frequency structure on two scales, one that is consistent with quenched
Galactic scintillation and broader spectral structure with
\,MHz. If the latter is due to scattering in the shared
M33/M31 CGM, our results constrain the Local Group plasma environment. We found
no accompanying persistent radio sources in the Apertif imaging survey data
Dutch Oncology COVID-19 consortium:Outcome of COVID-19 in patients with cancer in a nationwide cohort study
Aim of the study: Patients with cancer might have an increased risk for severe outcome of coronavirus disease 2019 (COVID-19). To identify risk factors associated with a worse outcome of COVID-19, a nationwide registry was developed for patients with cancer and COVID-19. Methods: This observational cohort study has been designed as a quality of care registry and is executed by the Dutch Oncology COVID-19 Consortium (DOCC), a nationwide collaboration of oncology physicians in the Netherlands. A questionnaire has been developed to collect pseudonymised patient data on patients' characteristics, cancer diagnosis and treatment. All patients with COVID-19 and a cancer diagnosis or treatment in the past 5 years are eligible. Results: Between March 27th and May 4th, 442 patients were registered. For this first analysis, 351 patients were included of whom 114 patients died. In multivariable analyses, age â„65 years (p < 0.001), male gender (p = 0.035), prior or other malignancy (p = 0.045) and active diagnosis of haematological malignancy (p = 0.046) or lung cancer (p = 0.003) were independent risk factors for a fatal outcome of COVID-19. In a subgroup analysis of patients with active malignancy, the risk for a fatal outcome was mainly determined by tumour type (haematological malignancy or lung cancer) and age (â„65 years). Conclusion: The findings in this registry indicate that patients with a haematological malignancy or lung cancer have an increased risk of a worse outcome of COVID-19. During the ongoing COVID-19 pandemic, these vulnerable patients should avoid exposure to severe acute respiratory syndrome coronavirus 2, whereas treatment adjustments and prioritising vaccination, when available, should also be considered
The insulin sensitizing effect of topiramate involves K-ATP channel activation in the central nervous system
Diabetes mellitus: pathophysiological changes and therap
Learning by heart The role of emotional education in raising school achievement
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